A safer world, more respectful.

FluoSphera’s technology better predicts the effects of molecules to help companies and organizations to protect people from harmful compounds, to discover more efficient drugs with less adverse side effects, and to reduce animal experimentation.

Environment

"We do not inherit the Earth from our ancestors, we borrow it from our children." Chief Seattle

1.6 million lives were lost in 2016 due to exposure to chemicals. However, most compounds released in the environmemt are not well-characterized.

There is an urgent need for exhaustive identification and characterization of harmful environmental compounds (United Nations Sustainable Development Goals 3 and 6) with new methods like FluoSphera, to address the complexity of human physiological responses, and to protect more efficiently populations from hazardous chemicals.

Health

"We need to refocus and adapt new methodologies [...] to understand disease biology in humans." Elias Zerhouni

9 out of 10 experimental drugs fail in clinical trials because we cannot accurately predict how they will behave in people based on laboratory studies.

By Caleb Jones.
By Caleb Jones.

Current in vitro methods poorly recapitulate the complexity of human physiology. Even animal models, albeit having a physiological system similar to the human body, weakly predict the effects of compounds on human health. Exchange of molecules between multiple tissues is key to predict the efficiency and the adverse side effects of experimental drugs before clinical trials. Our multi-culture method allows for the emergence of a new generation of in vitro assays with increased predictive power, able to detect subtle responses between several communicating tissues.

Alternatives to animal experimentation

"The love for all living creatures is the most noble attribute of man." Charles Darwin

Until now, the lack of in vitro methods recapitulating human physiology forced the use of animal models to tackle down major public health problems.

To reduce animal experimentation, in vitro methods with better physiological relevance have to be developed. At FluoSphera, we contribute to this paradigm shift with our cell-based assays mimicking the physiological communications exchanged between several human tissues. We get a step closer to a complex physiological system, like animals, but only using cells from human origin.

By Nick Fewings.